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To the Editor:—I have read with much interest the comments of A. W. Grace, M.D. (The Chick Embryo Antigen [Lygranum] Test for Lymphogranuloma Venereum, Arch. Dermat. & Syph.48:659 [Dec.] 1943) on the paper of Dr. Heisel and his collaborators (Heisel, E. B., and Stroud, G., III, in collaboration with Krause, M.; Hubler, W.; Cole, H. N., Jr., and Cord, R.: The Chick Embryo Antigen [Lygranum] Test for Lymphogranuloma Venereum: A Clinical Investigation, Arch. Dermat. & Syph.48:379 [Oct.] 1943).
The reason that my colleagues in this clinic and I chose a 7 mm. papule for a positive Frei reaction with the chick embryo antigen was that we desired to diagnose only specific papules and to be sure of our grounds. True, there is not much difference between a 6 mm. papule, employed by Dr. Grace and co-workers, and a 7 mm. papule. On the
Cole HN. CHICK EMBRYO ANTIGEN TEST FOR LYMPHOGRANULOMA VENEREUM. Arch Derm Syphilol. 1944;49(5):357. doi:10.1001/archderm.1944.01510110055015
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