In 1940 Behcet1 published the first description of a complex of symptoms consisting of aphthous ulcers in the mouth, chancroid-like ulcers of the genitals and changes in the eyes, alternating as retinitis, iridocyclitis, iritis, choroiditis and partial or complete atrophy of the optic nerve. All the symptoms are chronic and relapsing. In some cases eruptions similar to erythema nodosum have been reported. Jensen2 observed positive reactions to intradermal tests with tuberculin, Frei antigen, and dmelcos vaccine (a stabilized suspension of Ducrey bacilli) and even to injections of isotonic solution of sodium chloride, which signifies a nonspecific hyperactivity of the skin. The cause of the disease is not known; it does not respond to treatment, and it is not fatal. Not more than 10 cases have thus far been reported.
REPORT OF CASE
The patient, a 40 year old man born in Palestine, consulted
EPHRAIM H. TRIPLE SYMPTOM COMPLEX OF BEHCET: REPORT OF A CASE. Arch Derm Syphilol. 1944;50(1):37–38. doi:10.1001/archderm.1944.01510130040012
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: