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August 1944


Arch Derm Syphilol. 1944;50(2):96-98. doi:10.1001/archderm.1944.01510140019004

Tuberous sclerosis (epiloia), or Bourneville's disease, is a sufficiently uncommon clinical entity to justify the report of a case, particularly of an abortive case with variations from the classic symptom triad of idiocy, epilepsy and adenoma sebaceum as delineated by Vogt.1

In Europe the incidence in institutions for epileptic and feebleminded patients is about 0.6 per cent. In the United States it varies from 0.1 to 0.5 per cent in such institutions. Anderson2 estimated the general incidence of tuberous sclerosis to be about 0.0002 per cent. Ross and Dickerson3 expressed the opinion that the actual incidence is greater than this figure. However, many atypical cases undoubtedly go undiagnosed, particularly if the disease is not kept in mind. Consequently, it may be much more common than is suspected.

The disease generally manifests itself in infancy, though it may not be recognized until many years later. Usually