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Article
September 1944

CLEVELAND DERMATOLOGICAL SOCIETY

Arch Derm Syphilol. 1944;50(3):206-211. doi:10.1001/archderm.1944.01510150058017

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Abstract

Neurofibromatosis with Pregnancy. Presented by Dr. Max E. Krause and Dr. D. R. Printz.

O. K., a white woman aged 27, presented from the department of dermatology and syphilology, Cleveland City Hospital, complains of generalized tumors scattered over the body since childhood. She is five months pregnant, and in the last two months she has noticed an increase in the number and the size of the tumors. In addition, discrete firm movable masses have appeared in the neck, axillas and groins. Save for these firm masses, similar changes were observed during a previous pregnancy, with regression following delivery. There is no family history of neurofibromatosis.

There are multiple irregular tumors disseminated on the cutaneous surface. Some are in the skin; others are sessile, pedunculated or flattened. The tumors vary from 1 to 10 cm. in diameter. The superficial tumors are soft and have a normal epidermal covering. There

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