In 1942 I reported the results of a systematic attempt to inoculate the inhabitants of a hyperendemic area against oriental sore.1 The region comprised the settlements at the northern end of the Dead Sea, and most of the subjects were workers at the Palestine Potash Plant, situated in this area. The problem of oriental sore arose when some hundreds of workers and their families came to settle here, and since then the incidence of sores has steadily increased, so that now the region can be properly called hyperendemic. This sudden increase in morbidity in endemic districts is known; Hovnanian, of Aleppo, (1937)2 and Shah, of Delhi, (1941)3 have reported similar incidents.
In the first 167 cases results were encouraging.
It was my belief that it should be possible to sanitate an area by immunizing its inhabitants against the sore. The following factors
KATZENELLENBOGEN I. VACCINATION AGAINST ORIENTAL SORE: REPORT OF RESULTS OF FIVE HUNDRED AND FIFTY-FIVE INOCULATIONS. Arch Derm Syphilol. 1944;50(4):239–242. doi:10.1001/archderm.1944.01510160011005
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