Penicillin is the first therapeutic agent which has been found to be effective against both syphilis and gonorrhea. The amount of the drug used in treating gonorrhea, however, is usually about 100,000 units, a much smaller amount than that required in the treatment of syphilis, usually over 1,000,000 units. The use of penicillin for patients who have contracted gonorrhea and syphilis simultaneously will undoubtedly lead to unusual changes in the course of the syphilitic infection.
A patient acquiring both diseases simultaneously will probably first present symptoms of gonorrhea, since the period of incubation of this disease is usually shorter than that of syphilis. If such a patient is treated with the amount of penicillin given for gonorrhea, he is also receiving a small amount of antisyphilitic drug during the period of incubation of syphilis. The biologic changes which are likely to occur may be compared to those
CANIZARES O. PENICILLIN IN TREATMENT OF SIMULTANEOUS INFECTIONS OF SYPHILIS AND GONORRHEA. Arch Derm Syphilol. 1944;50(4):246. doi:10.1001/archderm.1944.01510160018008
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