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Article
October 1944

LOCAL TREATMENT OF PSORIASIS BY CHOLINE CHLORIDE: REPORT OF TWO CASES

Author Affiliations

CINCINNATI

From the Department of Dermatology and Syphilology, College of Medicine, University of Cincinnati.

Arch Derm Syphilol. 1944;50(4):250. doi:10.1001/archderm.1944.01510160022010
Abstract

Feeding of lecithin in the treatment of psoriasis has been favorably described. Results in a recent controlled hospital study1 by my colleagues and me justified continued study. In place of lecithin supplied orally over a period, the supposed active fraction, choline chloride, was prepared in pure form and directed into the lesions by iontophoresis.

The technical application of the iontophoresis was by procedures in common use, with the positive pole as the active pole and the negative pole as the inactive. Pure choline chloride in powder state was made up to a 1 per cent solution in water, and an asbestos pad 6 by 6 cm. was soaked with the solution at the positive pole. Isotonic solution of sodium chloride was used to moisten the large asbestos negative pole. Areas of equally severe involvement were used, and the upper extremities found entirely suitable in these cases. The maximum

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