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Article
October 1944

EFFECT OF FOLLICULOID HORMONES ON ABNORMAL SKIN: FURTHER OBSERVATIONS OF THE EFFECT OF ESTRADIOL ON THE SKIN OF MICE OF THE RHINO, HAIRLESS AND NAKED STRAINS

Author Affiliations

MONTREAL, CANADA

From the Department of Anatomy, McGill University.

Arch Derm Syphilol. 1944;50(4):261-263. doi:10.1001/archderm.1944.01510160033013
Abstract

In an earlier communication I described the main histologic characteristics of the structure of the skin of the so-called rhino mouse. I also showed that chronic local application of estradiol to the skin causes increased keratinization of the abnormal hair follicles and accentuates the resemblance of this congenitally abnormal skin to that characteristic of ichthyosis follicularis.1

In the course of continued experiments on this subject it was found that young animals of the rhino strain respond to folliculoids2 in an entirely different manner, inasmuch as in them a generalized cutaneous and subcutaneous edema develops. It was suspected that the reason for this was that their skin is not protected by the thick layer of keratinized epithelium which covers the surface of the old rhino mouse. In order to test this assumption, I repeated the experiment with so-called hairless mice. In this strain the skin is comparatively

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