When the sulfonamide drugs are used internally against specific organisms capable of producing serious or crippling systemic disease, certain safeguards are necessary: optimum dosage, alkalinization, dilution, determination of blood concentration, blood counts, etc., to avoid urinary, hematologic and other visceral ill effects. In spite of all precautionary measures, cutaneous and various types of reactions may appear that are considered more or less unavoidable. The administration of sulfonamide compounds in the presence of a major infection, however, is justified regardless of any untoward reactions that may develop.
It is my purpose to discuss the hazards of the local use of the sulfonamide compounds. This topic bears repetition because these drugs are being used more and more in treatment of comparatively minor infections of the skin and orificial mucous membranes. Such preparations may have certain immediate advantages over the older and conventional measures in selected cases. Their indiscriminate use
ABRAMOWITZ EW. HAZARDS OF THE EXTERNAL USE OF SULFONAMIDE COMPOUNDS. Arch Derm Syphilol. 1944;50(5):289–299. doi:10.1001/archderm.1944.01510170003001