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Article
January 1945

NUTRITIONAL DERMATOSES IN THE RAT: XI. VITAMIN A DEFICIENCY SUPERIMPOSED ON VITAMIN B COMPLEX DEFICIENCY

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES; BALTIMORE

From the Department of Dermatology, Johns Hopkins University School of Medicine, and the Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health.

Aided by a grant from the Rockefeller Foundation Fluid Research Fund.

Arch Derm Syphilol. 1945;51(1):17-25. doi:10.1001/archderm.1945.01510190022003
Abstract

The lesion of vitamin A deficiency has been defined by Wolbach and Howe1 as atrophy of many glands, arrest of growth, emaciation and replacement of many different single-layered epitheliums by stratified keratinizing epithelium. The process of the change from the cuboidal or columnar type of epithelium to the stratified type is known as keratinizing metaplasia, and it has been demonstrated numerous times in various epitheliums other than skin.2 There is no confusion regarding the primary histologic alterations and the resulting lesions of the eye, the paraocular glands and the respiratory, gastrointestinal and genitourinary systems. However, the question of the cutaneous lesion of vitamin A deficiency in the rat has been a matter of contention in many quarters, and it should be clarified. An analysis of the important early investigations of the cutaneous lesion of vitamin A deficiency in the rat explains some

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