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Article
February 1945

NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN DISEASE): PRELIMINARY REPORT OF A CASE CONTROLLED BY SULFAPYRIDINE

Author Affiliations

HONOLULU, TERRITORY OF HAWAII

Arch Derm Syphilol. 1945;51(2):94-99. doi:10.1001/archderm.1945.01510200018003
Abstract

The most recent reports of relapsing febrile nodular nonsuppurative panniculitis indicate that up to now the disease has not been found to respond to any treatment. Miller and Kritzler,1 in 1942, reported the first autopsy on a patient dying of this disease; they had given their patient sulfanilamide, sulfathiazole and sulfadiazine successively, with only transient benefit from sulfanilamide. They decided in retrospect that even this benefit was merely apparent and that the sulfonamide compounds were of no value. Sulfapyridine was apparently not tried. Christian's recent edition of Osler's testbook,2 which shortens the name to "relapsing febrile nonsuppurative panniculitis,'' contains the statement that ``treatment should be symptomatic" and does not refer to any reported successful treatment or mention the use of sulfonamide compounds. Larkin, De Sanctis and Margulis,3 in February 1944, reviewed the literature and reported the twentyeighth case of the disease

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