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Article
February 1945

CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH SUPERIMPOSED XANTHOMATOUS INFILTRATION: REPORT OF A CASE

Author Affiliations

CLEVELAND

From the Cleveland Clinic.

Arch Derm Syphilol. 1945;51(2):100-109. doi:10.1001/archderm.1945.01510200024004
Abstract

The occurrence of xanthomatous changes in lesions of a well established dermatosis is exceedingly rare. This process was thought by early investigators to be caused by fatty degeneration or pseudoxanthoma; in recent communications this type of xanthosis is classified with local lipidoses. This phenomenon cannot be differentiated from true xanthoma on the basis of chemical and histopathologic features; however, it differs clinically and probably in pathogenesis.

In classifying diseases of lipid metabolism, Urbach1 suggested the term ``resorption xanthelasma'' for this process and stated that it had been known to occur in scars of tertiary syphilids, herpes zoster, laparotomies and acrodermatitis atrophicans. More recently Urbach and Hill2 supported the assumption that in generalized or essential xanthomatosis there is lipid infiltration, while resorption xanthelasma is an imbibition process. Instead of the lipids' being derived from fatty degeneration of fibrous tissue, cells of

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