This investigation was undertaken to determine (a) whether the intravenous administration of neoarsphenamine and mapharsen affects the synthesis of cholic acid and, if so, (b) whether the oral administration of dehydrocholic acid for three days prior to and after the administration of the arsenicals will diminish the hepatotoxic action of these arsenicals.
This study was stimulated by the clinical report that the administration of sodium dehydrocholate ameliorates arsenical hepatitis.1 In a previous study2 we attempted to ascertain the physiologic rationale of the claim, and found that sodium dehydrocholate did not increase the excretion of the arsenicals in the bile. In fact, sodium dehydrocholate tended to decrease and sodium glycocholate and sodium taurocholate tended to increase the excretion of arsenic in the bile. These tendencies were not statistically significant and could have been due to chance or random sampling. However, an increased excretion of
ANNEGERS JH, DRILL VA, HABEGGER J, IVY AC, ATKINSON AJ. HEPATOTOXIC ACTION OF ARSENICALS: EFFECT OF NEOARSPHENAMINE AND MAPHARSEN ON CHOLIC ACID SYNTHESIS AND USE OF DEHYDROCHOLIC ACID TO DIMINISH HEPATOTOXIC ACTION OF MAPHARSEN. Arch Derm Syphilol. 1945;51(2):112–115. doi:10.1001/archderm.1945.01510200036006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: