In man, nutritional deficiencies of the various fractions of the B complex except thiamine are usually multiple; one or two symptoms are frequently present long before a fully developed disease syndrome makes its appearance. Examples of this limited effect are seen in cheilosis, greasy desquamation of the nasolabial folds, vascularization of the cornea which occurs in ariboflavinosis,1 stomatitis, gastritis, dermatitis, diarrhea and constipation which often occur singly in niacin deficiency2 and the nonpellagrous dermatoses such as those reported by Gross.3
In the experimental animal, changes involving the various tissues may be produced at will by withholding one or more of the various fractions of the B complex. These changes may be produced in the gastrointestinal tract, the nervous system, the hemopoietic system and the skin.
There are only two fractions of the B complex, niacin and riboflavin, which are known to affect cutaneous
STRYKER GV, HALBEISEN WA. DETERMINATION OF MACROCYTIC ANEMIA AS AN AID IN DIAGNOSIS OF CERTAIN DEFICIENCY DERMATOSES. Arch Derm Syphilol. 1945;51(2):116–123. doi:10.1001/archderm.1945.01510200040007
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