The use of penicillin in treatment of diseases of the skin has heretofore been curtailed by the scarcity of the drug. With its increased production during the past year, it is now available for use in treating diseases other than the severe generalized infections for which it was formerly reserved. The drug being relatively new and its toxic and irritating properties not completely determined, studies were instituted to determine the therapeutic value of the drug in certain selected groups of cutaneous diseases as well as the irritating or sensitizing properties of the substance itself.
In dermatologic therapy, there are two methods of administering penicillin: (1) local administration in the form of solutions and ointments and (2) intramuscular injection. To keep our studies as simple as possible, we selected a penicillin ointment for use locally and an aqueous solution of the sodium salt for intramuscular injection.
COHEN TM, PFAFF RO. PENICILLIN IN DERMATOLOGIC THERAPY: REPORT OF RESULTS IN ONE HUNDRED CASES. Arch Derm Syphilol. 1945;51(3):172–177. doi:10.1001/archderm.1945.01510210014002
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