The clinical picture of pityriasis rosea is one often seen in dermatoses caused by fungi. Because of this, I assumed that pityriasis rosea might be of fungous origin. I treated 90 patients with this disease at the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital with a 1: 500 dilution of trichophyton extract.1 All patients were tested for their sensitivity with 0.05 cc. of this extract intradermally, isotonic solution of sodium chloride being used as a control.
Ninety-five per cent of the patients proved nonsensitive to this dilution. Treatment was started forty-eight hours later. Intradermal injections of the same dilution were given three times a week in increasing doses (0.1, 0.15, 0.2, 0.25, 0.3 and 0.35 cc.) over a period of two weeks.
Itching, if it had been present, stopped after the second or third injection. The eruption disappeared entirely
VASS I. TREATMENT OF PITYRIASIS ROSEA WITH TRICHOPHYTON EXTRACT: A PRELIMINARY REPORT. Arch Derm Syphilol. 1945;51(3):203–204. doi:10.1001/archderm.1945.01510210045011
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