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Article
March 1945

ERYTHEMA MULTIFORME

Author Affiliations

Philadelphia.

Arch Derm Syphilol. 1945;51(3):228. doi:10.1001/archderm.1945.01510210070021

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Abstract

To the Editor:—It was with genuine interest that I read the article "Erythema Multiforme: Its Relationship to Herpes Simplex," by Dr. Nelson Paul Anderson (Arch. Dermat. & Syph.51:10 [Jan.] 1945) because I was the first to call attention to this relationship (Zentralbl. f. Haut- u. Geschlechtskr.46:413, 1933), one year before Forman and Whitwell. At that time I pointed out that erythema multiforme is rather frequently preceded by herpes labialis, the former appearing after an interval of about seven to ten days. I considered it at that time as a generalized herpetic exanthem. Four years later (Zentralbl. f. Haut- u. Geschlechtskr.57:12, 1937) I reported 20 cases in which this sequence was shown. Moreover, the corneas of many rabbits were inoculated with both the blood and the content of the vesicles of patients with erythema multiforme, and these materials were also injected intracisternally,

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