Exfoliative dermatitis due to the administration of sulfonamide drugs is relatively rare. A case with fatal termination following the use of sulfathiazole was reported by Weinstein and Domm (1941).1 Their case merits note in that the patient had a history of a severe cutaneous rash twelve years before, following arsenotherapy for syphilis. Johnson (1944)2 described a case of severe exfoliative dermatitis, with recovery, caused by sulfadiazine. The case to be described is of interest for the following reasons: 1. Sensitization apparently resulted from the previous ingestion of only 3 Gm. of sulfathiazole. 2. A repetition of the attack of exfoliative dermatitis was produced by the ingestion of only 1 Gm. of sulfathiazole. 3. Transverse furrows of the nails (Beau's lines) together with alopecia accompanied each attack of dermatitis.
REPORT OF CASE
F. P., first seen on June 20, 1944, was a highly intelligent
COOK MJ. EXFOLIATIVE DERMATITIS DUE TO SULFATHIAZOLE: REPORT OF A CASE CHARACTERIZED BY RECURRENT ATTACKS WITH BEAU'S LINES AND ALOPECIA. Arch Derm Syphilol. 1945;51(5):305–306. doi:https://doi.org/10.1001/archderm.1945.01510230015002
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