The more familiar manifestations of lymphogranuloma venereum are the result of a chronic, progressive involvement of the genitalia, rectum and associated lymphatic system. The virus may produce disease elsewhere as the result of inoculation in extragenital regions, such as the mouth, hands1 or upper respiratory tract.2 There may be an extensive spread from the original sites of involvement, as in the instances of colitis and colonic strictures caused by infection with the virus of this disease.3 A true metastatic infection may occur, as has been illustrated by isolation of the virus from the spinal fluid of a patient with meningoencephalitis.4
Accompanying these localized infections, in both the early and the later stages, there may be a variety of generalized constitutional effects and of certain more specific manifestations, as cutaneous eruptions and arthritis.5 Some, such as fever, headache, vomiting, loss of weight
HICKAM JB. CUTANEOUS AND ARTICULAR MANIFESTATIONS IN LYMPHOGRANULOMA VENEREUM: ACTIVATION OF THE DISEASE BY THE FREI TEST. Arch Derm Syphilol. 1945;51(5):330–336. doi:10.1001/archderm.1945.01510230040009
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