During the past twenty-five years a great majority of the investigations relating to the cause and treatment of psoriasis have been based on the concept that the psoriatic lesions are a local cutaneous expression of a generalized and constitutional disturbance. The underlying disturbance has been variously considered as owing to faults in metabolism involving proteins,1 carbohydrates2 or fats3; to vitamin depletion, particularly vitamins C4 and D,5 and to endocrine disturbances related to the thymus,6 thyroid,7 pituitary,8 gonads,9 adrenals10 or pancreas.11
The literature is both dogmatic and confusing. Evidence presented in support of each concept is for the most part balanced by reports expressing doubt or outright refutation. Striking "before and after" photographs are presented as visual proof of the benefits of a low nitrogen diet, a low fat diet or the use of adrenal cortex extract.
LeWINN EB, URBACH E. LOW POTASSIUM DIET IN TREATMENT OF PSORIASIS. Arch Derm Syphilol. 1945;51(6):398–401. doi:10.1001/archderm.1945.01510240044009
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