It is a well known fact that penicillin therapy produces few reactions. Urticaria seems to be the most common cutaneous reaction. In this report the possibility is suggested that penicillin acts as a photosensitizing agent.
Photodermatitis of vegetable origin has already been well studied.1 It is due in most instances to external contact of the patient with the plant followed by his exposure to sunlight. The action of chlorophyll seems to be an important factor in the photosensitizing properties of certain plants. The mechanism of photosensitization by a fungus is undoubtedly different, since fungi lack chlorophyll.
REPORT OF A CASE
A 25 year old white pilot was admitted to the hospital on Jan. 29, 1944 for penicillin therapy. He had had gonorrhea for three weeks. He had received one course of treatment with sulfathiazole from January 6 to January 11 and another, with sulfadiazine, from January 14 to
CANIZARES O. IS PENICILLIN A PHOTOSENSITIZING AGENT? Arch Derm Syphilol. 1945;52(1):17. doi:10.1001/archderm.1945.01510250022006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: