Any new medicine for general use which has the curative values attributed to penicillin and the almost complete lack of reports of reactions becomes a new agent for the treatment of many diseases, without the fear that is attached to the use of the more toxic benzene ring derivatives, such as the sulfonamide compounds, arsphenamine and others.
However, Jadassohn, Schaaf and Sulzberger 1 and their collaborators found that the products of fungi were capable of producing anaphylactic shock in guinea pigs and found that the uterine horn of a guinea pig (Schultz-Dale reaction) was even sensitized by these extracts.2 They were also able to elicit immediate reactions in cutaneous sites passively sensitized by a previous injection of serum containing Prausnitz-Küstner antibodies to tricophyton.
By the use of the Schultz-Dale phenomenon these investigators found that the extracts prepared from various species of dermatophytes all showed a common
LAMB JH. ALLERGIC REACTIONS DURING THE ADMINISTRATION OF PENICILLIN. Arch Derm Syphilol. 1945;52(2):93–95. doi:https://doi.org/10.1001/archderm.1945.01510260023005
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