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August 1945


Author Affiliations

President; Secretary March 28, 1944

Arch Derm Syphilol. 1945;52(2):123-128. doi:10.1001/archderm.1945.01510260053016

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Generalized Progressive Scleroderma. Presented by Dr. Howard Fox.

L. R., a Jewish housewife aged 39, first noticed a burning sensation in her chest about five months ago. It appeared suddenly and without apparent cause. She had previously been in good health. She soon noticed brown streaks on the front of the thighs and spent ten days in Mount Sinai Hospital (service of Dr. Isadore Rosen), where a diagnosis of scleroderma was made. The eruption gradually spread until at present it is generalized, symmetric and profuse, involving the trunk, the neck, the upper extremities as far as the wrists and the thighs. The hands, face and legs are unaffected. The skin is yellowish, shiny and hidebound in the affected areas. There is no tenderness on firm pressure. The patient complains of a burning sensation in certain areas and itching in others. She looks and feels sick.

At Mount Sinai Hospital, biopsy

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