Many modifications of intensive arsenotherapy have been introduced since the original five-day slow intravenous drip method was announced by Hyman, Chargin and Leifer.1 Further observations and reports on intensive methods have shown certain hazards, weaknesses, advantages and trends with such therapy. It is generally accepted that these methods compare favorably in efficiency with the older standard treatment of the eighteen month type. Excellent summaries on the present status of intensive arsenotherapy for early syphilis by Cole, Heisel and Stroud2 and McDermott3 are available.
The recent introduction of penicillin into the treatment of syphilis has confused still further the present chaotic state as to what is the most effective treatment of early syphilis today. This has occurred at a time when some semblance of fact is developing out of what must still be considered as experimental methods of intensive arsenotherapy. One can only await
SHAFFER LW. INTENSIVE ARSENOTHERAPY OF EARLY SYPHILIS. Arch Derm Syphilol. 1945;52(3):147–154. doi:10.1001/archderm.1945.01510270005001
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