The necessity for more rapid and more complete control of the contagious stages of early syphilis has been realized by every one familiar with the disease. The prolonged courses of treatment are tiring to patient and physician alike, and in these circumstances it is not to be wondered at that many—far too many—patients discontinue treatment long before the therapeutic possibility of cure is accomplished. Thus, inadequately treated patients are found in a large percentage of cases of early syphilis, and considerable evidence is at hand that inadequate treatment leaves the patient in a much less secure position than if he had no treatment at all. The natural immune developments take charge in untreated patients and attenuate the progress of the disease in many instances.
Great enthusiasm greeted the announcement of the results of treatment of early syphilis by a new method, first employed by Chargin, Leifer and
TROW EJ, DIXON HA. INTENSIVE TREATMENT OF EARLY SYPHILIS WITH OXOPHENARSINE HYDROCHLORIDE BY MULTIPLE INJECTIONS. Arch Derm Syphilol. 1945;52(3):155–161. doi:https://doi.org/10.1001/archderm.1945.01510270013002
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