Colloid degeneration of the skin is a rare dermatosis. Only 24 authentic cases have been recorded since Wagner1 first described the disease, in 1866. The case reports, pathologic features and nomenclature of colloid milium have been reviewed in recent articles by Way,2 Reuter and Becker3 and Arnold.4 Way,2 in 1942, was the first investigator to report the use of ascorbic acid in the treatment of colloid milium in a patient who had laboratory evidence of vitamin C deficiency. After an attempted correction of this deficiency the cutaneous lesions disappeared. In his report, Way2 stated that "the vitamin C deficiency existing in this case and the improvement seen following its attempted correction suggest that further studies may place this disease among the avitaminoses." Our patient with colloid degeneration of the skin received ascorbic acid therapy, as suggested by Way. The favor
ROBINSON SS, TASKER S. COLLOID DEGENERATION OF THE SKIN (COLLOID MILIUM): REPORT OF A CASE, WITH OBSERVATIONS ON ASCORBIC ACID THERAPY. Arch Derm Syphilol. 1945;52(3):180–181. doi:10.1001/archderm.1945.01510270038009
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