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Article
September 1945

A FAILURE OF PENICILLIN IN THE TREATMENT OF GRANULOMA INGUINALE: Report of a Case

Author Affiliations

Medical Corps, Army of the United States

Arch Derm Syphilol. 1945;52(3):182. doi:10.1001/archderm.1945.01510270040010

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Abstract

This is a report of an unsuccessful trial of penicillin in a case of granuloma inguinale. The attempt was made in the hope that a surer and quicker method could be found than the present regimen, which, though successful, requires prolonged treatment and careful watching for several months.

REPORT OF CASE

History.—A private aged 22 was admitted to the medical service of a general hospital on April 15, 1944, to which he had been transferred from a field hospital. A penile lesion had appeared as a small papule on March 8, 1944, and it had gradually increased to the size and shape of a button with a diameter of 1 cm. His most recent sexual intercourse had been Jan. 15, 1944. There was no pain with the lesion and no associated swelling. At the field hospital repeated dark field examinations showed no spirochetes and the Kahn reaction of the

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