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To the Editor:—I have noted that several observers have reported their results in the treatment of pyogenic dermatoses with penicillin in an ointment base. Inasmuch as I have been using a penicillin-containing ointment ever since October 1943 and have treated many hundreds of patients with this material, the following statement might be in order: After experimentation I have found that 800 units of penicillin per gram of vehicle is the most effective dose. The best vehicle was found to be a petrolatum-cholesterol ointment base (Aquaphor), when it is possible to obtain it. One of my most disappointing discoveries has been that sycosis vulgaris does not respond effectively to penicillin ointment, and to date I have treated about 30 patients with that disease. The results in treatment of impetigo contagiosa, as noted by others, are startling, and I have had patients with this disease who got well in
Goldberg LC. PENICILLIN IN THE TREATMENT OF CUTANEOUS DISEASES. Arch Derm Syphilol. 1945;52(3):184. doi:10.1001/archderm.1945.01510270042012
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