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Article
November 1945

EFFECT OF ENDOCRINE SUBSTANCES ON THE ADULT HUMAN SCALP

Author Affiliations

CHICAGO

From the Department of Endocrinology, service of Dr. H. Isaacs, and the Department of Dermatology, service of Dr. S. J. Zakon, Mount Sinai Hospital.

Arch Derm Syphilol. 1945;52(5):323-327. doi:10.1001/archderm.1945.01510290028004
Abstract

In a previous communication1 we presented evidence to show that injections of testosterone propionate given over a short period produce an increase in the number and the size of the sebaceous glands of the pubertal region in boys of prepubertal age. This report deals with the effect of testosterone and diethylstilbestrol on the scalps of adult males.

METHOD

Two men were selected for this study. Subject A was 18 years old, with beginning premature alopecia, having lost about 20 per cent of his scalp hair during the previous year. He was under our observation for seven consecutive months and received the following treatment: (a) 40 mg. of methyl testosterone daily by mouth for the first three months; (b) no treatment during the month that followed, and (c) 5 mg. of diethylstilbestrol daily by mouth for the last three months.

Subject B was 34 years old and had

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