An adequate supply of available oxygen is essential to the normal functioning of the cells of the body. Oxygen inadequacy may be localized to a small area so that local tissue anoxia may exist without anoxemia. Hippocrates more than two thousand years ago said: "So in one place the blood stops, in another it passes sluggishly, in another more quickly. The progress of the blood through the body proving irregular, all kinds of irregularities occur." Petersen1 has proved the validity of these words by showing experimentally that variation in the oxygen supply to the tissues is a common event. He believes that dysfunction of the mechanism which has to do with oxygen supply is probably the fundamental cause of disease. This report deals with results obtained in a series of patients afflicted with cutaneous diseases who were subjected to treatment designed to increase the oxygen supply of
SCHMIDT FR. TREATMENT OF DERMATOSES WITH VASODILATORS. Arch Derm Syphilol. 1945;52(5):344–346. doi:10.1001/archderm.1945.01510290049008
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