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Article
November 1945

WATERHOUSE-FRIDERICHSEN SYNDROME: REPORT OF A CASE

Author Affiliations

HONOLULU, TERRITORY OF HAWAII

Arch Derm Syphilol. 1945;52(5):391-394. doi:10.1001/archderm.1945.01510290096018
Abstract

The disease known as the Waterhouse-Friderichsen syndrome was described as an entity by Graham Little1 in 1901. He reviewed the literature and published 4 cases of his own. Waterhouse2 reported his case in 1911 and reviewed 15 others. He gave an accurate description of symptomatology and pathology.

In 1918 Friderichsen,3 in Germany, published his 2 cases and brought the literature up to date. There was little information as to the cause of the syndrome at this time. Maclagan and Cooke,4 in 1916, were perhaps the first to label the meningococcus as the etiologic agent. Reports have been printed in the German literature concerning the entity by Baumann5 and others. Aegerter6 and Sacks7 reviewed the literature in 1936 and 1937 respectively. Considerable publicity has been given to the syndrome during the last three to four years. Recent

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