Heineke1 was apparently the first to report that roentgen rays and rays from other radio-active substances can damage the hemopoietic organs; his extensive investigations were made on experimental animals. It is also known that radiation may be deleterious to normal human hemopoietic tissue. This knowledge has been gleaned chiefly from studies made on the personnel of diagnostic and therapeutic roentgen ray laboratories2 and from observations made on persons exposed in industry.3
Repeated accidental exposures of human beings to roentgen rays, radium and other radio-active substances, such as occur in the course of some occupations, have resulted in atrophic and hyperplastic changes in the hemopoietic system. The following alterations in the hemogram have been reported: (a) mild leukopenia with relative lymphocytosis; (b) neutropenia, which may develop into agranulocytosis and cause death; (c) aplastic anemia; (d) thrombopenia; (e) leukocytosis and leukemoid reactions, and,
PASCHER F, KANEE B, Reiss S. REACTIONS OF THE HEMOPOIETIC SYSTEM TO AGENTS USED IN THE TREATMENT OF DERMATOSES: EFFECTS OF LOW VOLTAGE ROENTGEN RAY THERAPY. Arch Derm Syphilol. 1946;53(1):1–5. doi:10.1001/archderm.1946.01510300004001
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