For many years the most valuable drugs in the treatment of lupus erythematosus1 have been gold and bismuth preparations. In cases of obstinate lupus erythematosus which does not respond to these conventional drugs and against which sundry methods have been used without success, any remedy which might improve the eruption, if only partially, is valuable. This is particularly true if the remedy is a comparatively nontoxic drug.
The organic arsenicals have long had a useful place in the treatment of lupus erythematosus. Neoarsphenamine, the silver arsphenamines, acetarsone and bismarsen have been used, with some favorable results reported for each. These facts made it seem worth while to test oxophenarsine hydrochloride, the arsenical having the best therapeutic index for syphilis, in the therapy of resistant lupus erythematosus.
In July 1942, Dr. M. B. Sulzberger first employed oxophenarsine hydrochloride in a case2 of widespread chronic discoid lupus erythema
HYMAN AB. OXOPHENARSINE HYDROCHLORIDE IN TREATMENT OF LUPUS ERYTHEMATOSUS. Arch Derm Syphilol. 1946;53(1):26–30. doi:10.1001/archderm.1946.01510300029006
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