ALL dermatologists, in fact all practitioners, are confronted frequently by patients with severely pruitic eruptions that fail to respond to the usual therapeutic agents. Such patients are a burden to their physician, to their family and to themselves. Besides leading to loss of weight, severe psychoneuroses or other manifestations their ailment may even eventuate in suicide. Therefore this preliminary report is offered on the as yet imperfectly understood action of theophylline ethylenediamine in the immediate relief of generalized and localized itching. The results are so dramatic as to warrant extensive research on this subject.
Theophylline ethylenediamine has been employed by intravenous injection in the treatment of patients with asthma and other diseases since 1940.1 Most authors feel that the use of the drug is safe when it is administered by this route. While the immediate symptoms, such as dyspnea, flushing, tachycardia and prickly sensations in the mouth
EPSTEIN E. THEOPHYLLINE ETHYLENEDIAMINE AS AN ANTIPRURITIC AGENT: Preliminary Report. Arch Derm Syphilol. 1946;53(3):281–284. doi:10.1001/archderm.1946.01510320071012
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