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Article
May 1946

TYROTHRICIN IN THE TREATMENT OF DISEASES OF THE SKIN

Author Affiliations

NEW YORK; ATLANTA, GA.

Arch Derm Syphilol. 1946;53(5):498-502. doi:10.1001/archderm.1946.01510340064008
Abstract

WITH the isolation of agents which are antagonistic to pathogenic micro-organisms, extensive investigation has been carried out in order to best utilize these antibiotics. Startling and almost miraculous results have been obtained by penicillin, which was isolated by Fleming1 in 1929. R. J. Dubos2 in 1939 first reported on the germicidal agent tyrothricin extracted from cultures of a soil bacterium. It is our purpose to review the results obtained in the treatment of some cutaneous diseases with the use of wet dressings and ointment containing tyrothricin.

The tyrothricin obtained was the concentrate which when properly diluted yielded an isotonic solution which contained 0.5 mg. of tyrothricin per cubic centimeter. This was obtainedin 20 cc. vials and was diluted to 1,000 cc. with sterile distilled water. This was applied to the affected areas as a wet dressing, so that the lesions were constantly dampened with

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