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May 1946


Author Affiliations

President; Secretary Nov. 15, 1944

Arch Derm Syphilol. 1946;53(5):540-551. doi:10.1001/archderm.1946.01510340106017

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Pigmentation Following Morphea (and Arsenic?). Presented by Dr. Earle R. Pace.

Mrs. J. L., a white woman aged 22, presents a widespread pigmentary disturbance of the neck, trunk and proximal segments of the extremities. The onset coincided with the onset of menstruation ten years ago. The earliest patches were in the cubital fossae and on the upper part of the inner thighs and were hard, thickened and inflexible. New patches have appeared from time to time, all eventually resulting in pigmentation as now seen.

At present she shows coin-sized to egg-sized brown, pigmented patches, which fuse into sheets in many areas. The pigmentation is a smooth tan to brown discoloration, flecked with lighter spots. On the trunk, particularly on the abdominal wall, it is diffuse and nonmarginated and resembles arsenical pigmentation.

The central parts of some larger patches, notably in the cubital fossae and on the thighs, show

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