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Article
June 1946

HISTOPATHOLOGY OF CUTANEOUS CANCER

Arch Derm Syphilol. 1946;53(6):599-601. doi:10.1001/archderm.1946.01510350039008
Abstract

IN a brief review of a large subject, only the important features can be enumerated with little or no explanation of many others being made. Therefore, I believe, I need not consider the adnexal neoplasms, as syringoma, trichoepithelioma, multiple benign cystic epithelioma and the others. These are either nevi or nevoid lesions and are not malignant.

Epitheliomas of the skin are epithelial neoplasms which are malignant. There are three large groups, depending on the cells involved: basal cell, prickle cell and undifferentiated cell. These may be subdivided into intraepidermic and extraepidermic, and these, in turn, may be either "en masse" or "disseminated."

Basal cell epithelioma may occur anywhere on the skin and even on the mucous membrane. The growth is composed entirely of basal cells which have hyperchromatic nuclei and only a small amount of cytoplasm, and the cell outlines are not present. While normal basal cells contain

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