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Article
June 1946

EPIDERMOLYSIS BULLOSA SIMPLEX OF THE HANDS AND THE FEET: A Genetic Study of the Hereditary Type

Author Affiliations

Assistant Professor of Dermatology and Syphilology, University of Michigan Medical School; Junior Geneticist, University of Michigan ANN ARBOR, MICH.

Studies and contributions from the Department of Dermatology and Syphilology of the University of Michigan Medical School; service of Dr. Udo J. Wile and Dr. Arthur C. Curtis.

Studies and contributions from the Department of Human Heredity of the Laboratory of Vertebrate Biology, University of Michigan.

Arch Derm Syphilol. 1946;53(6):610-619. doi:10.1001/archderm.1946.01510350050011
Abstract

EPIDERMOLYSIS bullosa is a disease of the skin which is captious in its various manifestations. Of these, involvement of just the hands and the feet without any residual scarring or other cutaneous changes is one of the most unusual.

In 1895 Elliot1 reported the first of such cases, that of a 30 year old white man who had suffered from the disease since he was 5 years of age. The bullae manifested themselves especially in warm weather. The bullous elevations arose without precedent redness after walking or rowing or after using a hammer or screwdriver. There was an associated hyperhidrosis of the hands and the feet and often bromhidrosis of the latter. There were no subjective symptoms except pain after the bullae had ruptured and left raw surfaces. Examination revealed bullae of all sizes on the hands and the feet, some of which had arisen on the latter during

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