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Article
June 1946

TREATMENT OF CONGENITAL AND OF ACQUIRED SYPHILIS IN INFANTS AND IN CHILDREN BY PENICILLIN

Author Affiliations

Consultant Syphilologist, Midwestern Medical Center, United States Public Health Service; Past Acting Surgeon (R), Midwestern Medical Center, United States Public Health Service; Senior Surgeon, Midwestern Medical Center, United States Public Health Service; Bacteriologist, Snodgras Laboratory, St. Louis City Hospital; Assistant Surgeon (R), Midwestern Medical Center, United States Public Health Service; ST. LOUIS

From the St. Louis Children's Hospital, Washington University.; From the St. Louis City Hospital, Department of Pediatrics.

Arch Derm Syphilol. 1946;53(6):625-632. doi:10.1001/archderm.1946.01510350065013
Abstract

FOR the past two years syphilis in adults has been treated with penicillin, and at the present time it is thought that this form of therapy has been encouragingly successful. Sixteen months ago, several of us became interested in the possibility of treating babies and children with congenital and with acquired syphilis with penicillin. As penicillin is less toxic than arsenicals and heavy metals, it was felt that an effort should be made to determine whether its therapeutic efficiency was comparable to that of arsenicals and heavy metals.

In the past sixteen months, we have treated 39 syphilitic children with penicillin. Eleven of these had acquired syphilis, and 28 had congenital syphilis. There has been 1 death in our series and 3 mild reactions. We do not as yet have any idea of the optimal dosage of penicillin in the treatment of syphilis. We have used total dosages of

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