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Article
June 1946

OPTIMAL ZONE REACTION IN THE DIAGNOSIS AND TREATMENT OF SYPHILIS

Arch Derm Syphilol. 1946;53(6):633-642. doi:10.1001/archderm.1946.01510350073014
Abstract

A PRELIMINARY report is herewith presented of a supplementary serologic procedure to serodiagnostic tests. This procedure, referred to as optimal zone procedure, is applicable to known cases of syphilis. When applied to such cases, it gives promise to be of value: (1) in supporting the diagnosis of clinically positive, seronegative syphilis; (2) in providing an index of cure in syphilis more dependable than serodiagnostic tests, especially in evaluating rapid methods of treatment, and (3) in demonstrating different precipitation patterns in different situations in syphilis—patterns which give indication of having clinical significance.

1. BASIS OF OPTIMAL ZONE PROCEDURE

The optimal zone procedure is based on an extension of the serum: antigen ratios from three, employed in the standard Kahn test, to ten and, in some cases, fifteen ratios. Twenty years ago,1 when my interest was directed to the principles governing the phenomenon of precipitation in syphilis which laid the

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