ONLY meager information on the outcome of treated and untreated latent syphilis is available in the literature. The reason for this is that no information of value can be obtained except by follow-up studies of patients observed over a period of many years. It is our opinion that at least ten years, and preferably a lifetime, must intervene from the time of the first observation of the patient before any attempt can be made to evaluate the efficacy of treatment rendered or to determine the outcome of untreated syphilis. Furthermore, only by observation of such patients over a period of many years can data be obtained as to the proper amount of treatment that patients with latent syphilis should receive to prevent complications in later life and to determine what relation, if any, serologic tests have on the final clinical outcome. Most texts on syphilology cite the figures compiled
JORDON JW, DOLCE FA. LATENT SYPHILIS: Study of One Hundred and Sixty-Nine Cases Observed Ten Years or More. Arch Derm Syphilol. 1946;54(1):1–18. doi:10.1001/archderm.1946.01510360005001
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