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Urticaria is one of the few known untoward reactions of penicillin therapy. From May to November 1945 I observed 8 patients in the Royal Victoria Hospital in whom a generalized pruritus occurred after parenteral penicillin treatment and decided dermographia was exhibited. The dermographia started in 3 cases during therapy and in the others from five to thirteen days after the conclusion of therapy and lasted from two to eleven weeks. Five of the patients gave a history of previous eczema, urticaria or hay fever, but none suffered previously from dermographia. No relation to sex, age or an underlying condition was observed in this small group.
In all patients now receiving penicillin therapy, sensitivity to histamine will be determined before and after treatment and the results reported after sufficient material has been collected.
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KALZ F. DERMOGRAPHIA; ANOTHER SIDE EFFECT OF PENICILLIN THERAPY. Arch Derm Syphilol. 1946;54(1):66. doi:10.1001/archderm.1946.01510360070013
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