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Article
July 1946

PASSIVE IMMUNIZATION OF PEMPHIGUS VULGARIS

Author Affiliations

Philadelphia.

Arch Derm Syphilol. 1946;54(1):71. doi:10.1001/archderm.1946.01510360075017

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Abstract

To the Editor:—Drs. Arthur W. Grace and Leon D. Hellman published a paper (Pemphigus Vulgaris: Successul Results Following Transfusion with Blood from Persons Who Had Recovered from the Disease, Arch. Dermat. & Syph.53:249 [March] 1946) which implies that this method is a new and original one. As early as 1936 L. Kumer (in discussion on Urbach, E.: Versuche einer aktiven Immunisierung von Pemphiguserkrankungen, Zentralbl. f. Haut- u. Geschlechtskr.52:277, 1936) reported some astonishing results with injection of blood or blood serum from persons convalescent from pemphigus into patients with this disease. Similar experiences were described by me (same reference). Since convalescent blood or serum is difficult to obtain, I introduced the transfusion of immune serum from rabbits which had been experimentally infected with pemphigus virus and had recovered from this disease (Urbach, E., and Wolfram, S.: Arch. Dermat. & Syph.33:788 [May] 1936). Since repeated

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