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To the Editor:—Six patients with chronic urticaria under treatment with Benadryl complained that the medication made them so sleepy that it was not practical for them to use it except at bedtime. All were instructed to take half of a 10 mg. tablet of amphetamine sulfate (Benzedrine) at the same time as the Benadryl. All except 1 patient reported complete relief of the annoying drowsiness, and this one was relieved by taking three-fourths of an amphetamine sulfate tablet. The undesirability of prolonged habitual use of amphetamine sulfate is recognized, but these patients required only one or two doses a day, which seems reasonably safe and at least preferable to the obvious alternatives.
Arnold HL. BENADRYL IN CHRONIC URTICARIA. Arch Derm Syphilol. 1946;54(1):71. doi:10.1001/archderm.1946.01510360075018
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