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August 1946


Arch Derm Syphilol. 1946;54(2):136-149. doi:10.1001/archderm.1946.01510370020003

mentRECENT widespread employment of penicillin in the treatment of infectious dermatoses makes desirable a summary of the indications for and the contraindications to its use, as well as an analysis of the results to be expected from various methods of administration.

As reported in a previous communication,1 penicillin in a watersoluble ointment base was used in the treatment of 40 patients with treatment-resistant cutaneous infections. None of the patients had previously received penicillin therapy. Cure was obtained in 66.6 per cent of patients with uncomplicated pyoderma, with the individual manifestations responding as follows: impetigo 85.7 per cent, pustular folliculitis 66.6 per cent, sycosis 60 per cent and infectious eczematoid dermatitis 55.5 per cent. Tests for sensitivity to penicillin were made on most of the patients. The trench plate method was used. In this procedure a trench was made across a blood agar plate by removing a strip