The purpose of this paper is to suggest a modified formula to be used in making carbon dioxide slush for the treatment of acne and postacne scarring. The benefits, failures, indications, contraindications and methods of use have been discussed in detail by other authors.1
My study consisted of the use of slush treatment for acne and postacne scarring on 150 patients, ethyl acetate instead of acetone being used in its formula. The results of treatment were good, definitely paralleling those of Dobes and Keil.1a
The substitution of ethyl acetate for acetone was made for the following reasons:
1. A better and longer-lasting slush is obtained, which makes it easier to handle. Ethyl acetate (boiling point, 77 C.; specific gravity, 0.900), also a fat solvent, is similar in action to acetone (boiling point, 56.5 C.; specific gravity, 0.788) but is less volatile.
2. The odor of ethyl acetate is
ZUGERMAN I. A FORMULA FOR CRYOTHERAPY FOR ACNE AND POSTACNE SCARRING. Arch Derm Syphilol. 1946;54(2):209–210. doi:10.1001/archderm.1946.01510370093012
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: