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Article
November 1946

PROGRESSIVE SYPHILITIC OPTIC ATROPHY BENEFITED BY COMBINED PENICILLIN AND FEVER THERAPY: Report of a Case

Arch Derm Syphilol. 1946;54(5):566-568. doi:10.1001/archderm.1946.01510400072011
Abstract

THE DRAMATIC improvement in vision achieved by the combined use of penicillin and fever therapy in a case of advancing syphilitic optic atrophy prompts this report.

S. M., a white man aged 34, noticed dimness of vision in the left eye late in November 1944. At the beginning, this blurring was inconstant and limited to "the inside, near my nose." Gradually this disturbance became constant and more extensive until, finally, all the vision was gone. When the patient consulted Dr. W. E. Bruner in January 1945, there was total blindness of the left eye. Dr. Bruner found pallor of the nerve head on the left side and also Argyll-Robertson pupils.

S. M. was referred to me by Dr. Bruner and was examined on Feb. 1, 1945. At the initial visit he had total blindness in the left eye and rather casually mentioned some visual difficulty with the right

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