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November 1946


Arch Derm Syphilol. 1946;54(5):569. doi:10.1001/archderm.1946.01510400075013

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To the Editor:—The report of Dr. Herman Goodman in the Archives of Dermatology and Syphilology, July 1946, page 62, is highly provocative in that it brings into sharp focus our understanding of dosage in topical therapy for the skin. Essentially, the establishment of effective dosage of an active drug involves maintenance of a proper concentration of the drug in the tissue concerned. And so, for internal therapy, dosage is based on body weight, and exhibition of the drug is repeated at proper intervals to keep adequate its concentration in the organism over the required period. For topical treatment the same principles operate except that surface area is substituted for body weight in estimating the anticipated concentration of the drug in skin, for the skin covered by the medicament is accepted as the only area of skin receiving therapy.

Vehicles for topical drugs serve the purpose, among others, of

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