[Skip to Content]
[Skip to Content Landing]
December 1946


Arch Derm Syphilol. 1946;54(6):713-714. doi:10.1001/archderm.1946.01510410079009

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


With the introduction of penicillin, emphasis was placed on the factor of freedom from complications produced by the antibiotic agent. After its use over a period, reports of reactions began to appear in the literature. Although the majority of the reactions have been mild to moderate, physicians interested in immunology have been awaiting more serious manifestations. To date it would seem that there has never been, a biologic product discovered which could be introduced into the human body without producing some reactions. Fortunately, the administration of penicillin has been accompanied with few adverse side effects. It is, however, a potent biologic agent and must be used with discrimination under adequate supervision.

Two cases of severe complications of penicillin therapy are reported.


Case 1.—An aircraft armourer was treated with penicillin because of a recalcitrant pustulosquamous dermatitis of the palms and soles, of one year's duration. Culture of

First Page Preview View Large
First page PDF preview
First page PDF preview