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Article
January 1947

AGRANULOCYTOSIS: Report of Twelve Cases in Which It Followed Intensive Arsenotherapy for Syphilis

Author Affiliations

PATERSON, N. J.; BIRMINGHAM, ALA.; LOS ANGELES

Dr. Fisher was formerly Surgeon, Dr. Holley, Passed Assistant Surgeon, and Dr. Fein, Passed Assistant Surgeon in the United States Public Health Service.

Arch Derm Syphilol. 1947;55(1):57-66. doi:10.1001/archderm.1947.01520010061007
Abstract

AGRANULOCYTOSIS, in our experience, has been a rather frequent and annoying complication during the course of treatment of syphilis by intensive methods. This paper concerns itself with a report of 12 cases in which this complication was encountered, covering a period of one year.1 It occurred in the course of therapy based on the following regimens:

  1. Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty-five day schedule: Oxophenarsine hydrochloride (mapharsen) was administered six days a week for a total of twenty-two injections, with a maximum individual dose of 60 mg., and bismuth subsalicylate in oil was administered concurrently, 200 mg. every five days.

  2. Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty day schedule (Schock method): One dose of oxophenarsine hydrochloride was given daily for twenty consecutive days, the maximum dose being 70 mg., and bismuth subsalicylate in oil was administered concurrently 200 mg. every

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