AGRANULOCYTOSIS, in our experience, has been a rather frequent and annoying complication during the course of treatment of syphilis by intensive methods. This paper concerns itself with a report of 12 cases in which this complication was encountered, covering a period of one year.1 It occurred in the course of therapy based on the following regimens:
Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty-five day schedule: Oxophenarsine hydrochloride (mapharsen) was administered six days a week for a total of twenty-two injections, with a maximum individual dose of 60 mg., and bismuth subsalicylate in oil was administered concurrently, 200 mg. every five days.
Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty day schedule (Schock method): One dose of oxophenarsine hydrochloride was given daily for twenty consecutive days, the maximum dose being 70 mg., and bismuth subsalicylate in oil was administered concurrently 200 mg. every