AGRANULOCYTOSIS, in our experience, has been a rather frequent and annoying complication during the course of treatment of syphilis by intensive methods. This paper concerns itself with a report of 12 cases in which this complication was encountered, covering a period of one year.1 It occurred in the course of therapy based on the following regimens:
Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty-five day schedule: Oxophenarsine hydrochloride (mapharsen) was administered six days a week for a total of twenty-two injections, with a maximum individual dose of 60 mg., and bismuth subsalicylate in oil was administered concurrently, 200 mg. every five days.
Oxophenarsine hydrochloride and bismuth subsalicylate— multiple injections on a twenty day schedule (Schock method): One dose of oxophenarsine hydrochloride was given daily for twenty consecutive days, the maximum dose being 70 mg., and bismuth subsalicylate in oil was administered concurrently 200 mg. every
FISHER S, HOLLEY HL, FEIN G. AGRANULOCYTOSIS: Report of Twelve Cases in Which It Followed Intensive Arsenotherapy for Syphilis. Arch Derm Syphilol. 1947;55(1):57–66. doi:10.1001/archderm.1947.01520010061007
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